ELK1 Recombinant Rabbit Monoclonal Antibody [SU32-05] (ET1608-19)

UNIPROT #

P19419

PROTEIN NAME

ELK1

SYNONYMS

ELK 1 antibody;Elk1 antibody;ELK1 member of ETS oncogene family antibody;ELK1 protein antibody;ELK1, ETS transcription factor antibody;ELK1_HUMAN antibody;ELK2 member of ETS oncogene family antibody;ETS domain containing protein Elk 1 antibody;ETS domain containing protein Elk1 antibody;ETS domain protein Elk1 antibody;ETS domain-containing protein Elk-1 antibody;ETS like gene 1 antibody;Member of ETS oncogene family antibody;Oncogene Elk1 antibody;Tyrosine kinase (ELK1) oncogene antibody

SEQUENCE SIMILARITIES

Belongs to the ETS family.

TISSUE SPECIFICITY

Lung and testis.

POST-TRANSLATIONAL MODIFICATION

Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.; On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences. Elk1 plays important roles in various contexts, including long-term memory formation, drug addiction, Alzheimer's disease, Down syndrome, breast cancer, and depression. Given its role as a transcription factor, Elk1 is expressed in the nuclei of non-neuronal cells. The protein is present in the cytoplasm as well as in the nucleus of mature neurons. In post-mitotic neurons, a variant of Elk1, sElk1, is expressed solely in the nucleus because it lacks the NES site present in the full-length protein. Moreover, while Elk1 is broadly expressed, actual levels vary among tissues. The rat brain, for example, is extremely rich in Elk1, but the protein is exclusively expressed in neurons.