CD161 Mouse Monoclonal Antibody [A8E1] (HA601063)

UNIPROT #

Q12918

PROTEIN NAME

CD161

SYNONYMS

C-type lectin domain family 5 member B antibody;CD161 antibody;CLEC5B antibody;HNKR-P1a antibody;Killer Cell Lectin like Receptor Subfamily B Member 1 antibody;Killer cell lectin-like receptor subfamily B member 1 antibody;KLRB1 antibody;KLRB1_HUMAN antibody;Natural killer cell surface protein P1A antibody;NKR antibody;NKR P1 antibody;NKR-P1A antibody;NKRP1 antibody;NKRP1A antibody

SUBCELLULAR LOCATION

Membrane

FUNCTION

Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.