CD22 Recombinant Rabbit Monoclonal Antibody [PO00-31] (HA721157)

UNIPROT #

P20273

PROTEIN NAME

CD22

SYNONYMS

B cell receptor CD22 precursor antibody;B lymphocyte cell adhesion molecule antibody;B-cell receptor CD22 antibody;B-lymphocyte cell adhesion molecule antibody;BL CAM antibody;BL-CAM antibody;BLCAM antibody;CD 22 antibody;CD22 antibody;CD22 antigen antibody;CD22 molecule antibody;CD22 protein antibody;CD22_HUMAN antibody;Lectin 2 antibody;Leu14 antibody;Lyb8 antibody;MGC130020 antibody;sialic acid binding Ig like lectin 2 antibody;Sialic acid binding immunoglobulin like lectin 2 antibody;Sialic acid-binding Ig-like lectin 2 antibody;SIGLEC 2 antibody;Siglec-2 antibody;SIGLEC2 antibody;T cell surface antigen Leu 14 antibody;T-cell surface antigen Leu-14 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. CD22 may be a useful marker for phenotyping mature leukemias, as CD22 membrane expression has been shown to be limited to the late differentiation stages between mature B cells (CD22+) and plasma cells (CD22-). CD22 is also strongly expressed in hairy cell leukemia.