AKT1 Recombinant Rabbit Monoclonal Antibody [PSH0-50] (HA721364)

UNIPROT #

P31749

PROTEIN NAME

AKT1

SYNONYMS

AKT 1 antibody;AKT antibody;AKT1 antibody;AKT1_HUMAN antibody;C AKT antibody;cAKT antibody;MGC99656 antibody;PKB alpha antibody;PKB antibody;PKB-ALPHA antibody;PRKBA antibody;Protein Kinase B Alpha antibody;Protein kinase B antibody;Proto-oncogene c-Akt antibody;RAC Alpha antibody;RAC antibody;Rac protein kinase alpha antibody;RAC Serine/Threonine Protein Kinase antibody;RAC-alpha serine/threonine-protein kinase antibody;RAC-PK-alpha antibody;v akt murine thymoma viral oncogene homolog 1 antibody;vAKT Murine Thymoma Viral Oncogene Homolog 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Cell membrane.

FUNCTION

RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. It is commonly referred to as PKB, or by both names as "Akt/PKB". The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mice lacking Akt1 display a 25% reduction in body mass, indicating that Akt1 is critical for transmitting growth-promoting signals, most likely via the IGF1 receptor. Mice lacking Akt1 are also resistant to cancer: They experience considerable delay in tumor growth initiated by the large T antigen or the Neu oncogene. A single-nucleotide polymorphism in this gene causes Proteus syndrome.