GNAQ Recombinant Rabbit Monoclonal Antibody [JE65-59] (HA721328)

UNIPROT #

P50148

PROTEIN NAME

GNAQ

SYNONYMS

CMC1 antibody;G alpha Q antibody;G protein alpha Q antibody;G protein subunit alpha q antibody;G-ALPHA-q antibody;GAQ antibody;GNAQ antibody;GNAQ_HUMAN antibody;guanine nucleotide binding protein (G protein), q polypeptide antibody;Guanine nucleotide binding protein alpha q antibody;guanine nucleotide binding protein G protein q polypeptide antibody;Guanine nucleotide binding protein G q subunit alpha antibody;Guanine nucleotide-binding protein alpha-q antibody;Guanine nucleotide-binding protein G(q) subunit alpha antibody;SWS antibody

SUBCELLULAR LOCATION

Cell membrane, Golgi apparatus, Nucleus, Nucleus membrane.

FUNCTION

Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11 (its paralogue), it functions as a Gq alpha subunit. Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230). Mutations in this gene have been found associated to cases of Sturge–Weber syndrome and port-wine stains.