SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20] (HA721316)

UNIPROT #

P78324

PROTEIN NAME

SIRP alpha

SYNONYMS

Signal regulatory protein alpha type 1 antibody;Bit antibody;Brain Ig like molecule with tyrosine based activation motifs antibody;Brain Ig-like molecule with tyrosine-based activation motifs antibody;Brain immunoglobulin like molecule with tyrosine based activation motifs antibody;CD172 antigen like family member A antibody;CD172 antigen-like family member A antibody;CD172a antibody;CD172a antigen antibody;Inhibitory receptor SHPS-1 antibody;Macrophage fusion receptor antibody;MFR antibody;MYD 1 antibody;Myd 1 antigen antibody;MyD-1 antigen antibody;p84 antibody;Protein tyrosine phosphatase non receptor type substrate 1 antibody;PTPNS1 antibody;SHP substrate 1 antibody;SHPS-1 antibody;SHPS1 antibody;SHPS1_HUMAN antibody;Signal regulatory protein alpha 2 antibody;Signal regulatory protein alpha 3 antibody;Signal regulatory protein alpha antibody;Signal regulatory protein alpha type 2 antibody;Signal-regulatory protein alpha-1 antibody;Signal-regulatory protein alpha-2 antibody;Signal-regulatory protein alpha-3 antibody;SIRP antibody;Sirp-alpha-1 antibody;Sirp-alpha-2 antibody;Sirp-alpha-3 antibody;SIRPA antibody;SIRPalpha antibody;SIRPalpha1 antibody;SIRPalpha2 antibody;SIRPalpha3 antibody;Tyrosine phosphatase SHP substrate 1 antibody;Tyrosine protein phosphatase non receptor type substrate 1 antibody;Tyrosine-protein phosphatase non-receptor type substrate 1 antibody

SUBCELLULAR LOCATION

Membrane

FUNCTION

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB1. Binds PTK2B.