SorLA Recombinant Rabbit Monoclonal Antibody [JE35-52] (HA721337)

UNIPROT #

Q92673

PROTEIN NAME

SorLA

SYNONYMS

C11orf32 antibody;FLJ21930 antibody;FLJ39258 antibody;gp250 antibody;LDLR relative with 11 ligand binding repeats antibody;LDLR relative with 11 ligand-binding repeats antibody;Low density lipoprotein receptor relative with 11 ligand binding repeats antibody;Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody;LR 11 antibody;LR11 antibody;LRP 9 antibody;LRP9 antibody;Mosaic protein LR11 antibody;SORL 1 antibody;SORL_HUMAN antibody;SORL1 antibody;SorLA 1 antibody;SorLA antibody;SorLA-1 antibody;Sortilin related receptor antibody;Sortilin related receptor L(DLR class) A repeats containing antibody;Sortilin-related receptor antibody;Sorting protein related receptor containing LDLR class A repeats antibody;Sorting protein-related receptor containing LDLR class A repeats antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Secreted.

FUNCTION

Sortilin-related receptor, L(DLR class) A repeats containing is a protein that in humans is encoded by the SORL1 gene. SORL1 (also known as SORLA, SORLA1, or LR11) is a neuronal apolipoprotein E receptor, the gene for which is predominantly expressed in the central nervous system. Mutation of the gene for apolipoprotein E (APOE) is predictive of Alzheimer's disease. Lack of the APOE receptor is suspected to be a contributory factor to Alzheimer's: a significant reduction in SORL1 (LR11) expression has been found in brain tissue of Alzheimer's disease patients. The APOE receptor has also been linked with regulation of amyloid precursor protein, faulty processing of which is implicated in Alzheimer's. A more recent study by a group of international researchers supports the proposition that SORL1 plays a part in seniors developing Alzheimer's disease, the findings being significant across racial and ethnic strata.