BACE1 Recombinant Rabbit Monoclonal Antibody [PSH05-19] (HA722244)

UNIPROT #

P56817

PROTEIN NAME

BACE1

SYNONYMS

APP beta secretase antibody;Asp 2 antibody;ASP2 antibody;Aspartyl protease 2 antibody;BACE 1 antibody;BACE antibody;BACE1 antibody;BACE1_HUMAN antibody;Beta secretase 1 antibody;Beta secretase antibody;Beta site amyloid beta A4 precursor protein cleaving enzyme antibody;Beta site amyloid precursor protein cleaving enzyme 1 antibody;Beta site amyloid precursor protein cleaving enzyme antibody;Beta site APP cleaving enzyme 1 antibody;Beta site APP cleaving enzyme antibody;Beta-secretase 1 antibody;Beta-site amyloid precursor protein cleaving enzyme 1 antibody;Beta-site APP cleaving enzyme 1 antibody;FLJ90568 antibody;HSPC104 antibody;Memapsin 2 antibody;Memapsin-2 antibody;Memapsin2 antibody;Membrane associated aspartic protease 2 antibody;Membrane-associated aspartic protease 2 antibody;Transmembrane aspartic proteinase Asp2 antibody

SUBCELLULAR LOCATION

Cell membrane, Golgi apparatus, trans-Golgi network, Endoplasmic reticulum, Endosome, Cell surface, Cytoplasmic vesicle membrane, Membrane raft, Lysosome, Late endosome, Early endosome, Recycling endosome, Cell projection, axon, dendrite.

FUNCTION

Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons. BACE1 is an aspartic acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer, its cytoplasmic tail is required for the correct maturation and an efficient intracellular trafficking, but doesn't affect the activity. It is produced as a pro-enzyme, the endoproteolitc removal occurs after BACE leaves Endoplasmic reticulum, in the Golgi apparatus. In addition the pro-peptide receives additional sugars to increase the molecular mass. and the tail became a palmitoylated. The BACE1 expression is influenced by the inflammatory state: during AD the cytokines reduce the PPAR1 an inhibitor of BACE1 mRNA).