Fast Myosin Skeletal Heavy chain Recombinant Rabbit Monoclonal Antibody [PSH05-12] (HA722228)

UNIPROT #

P12882

PROTEIN NAME

Fast Myosin Skeletal Heavy chain

SYNONYMS

adult 1 antibody;MYH1 antibody;MYH1_HUMAN antibody;MyHC-2x antibody;MyHC-IIx/d antibody;Myosin heavy chain 1 antibody;Myosin heavy chain 2x antibody;Myosin heavy chain antibody;Myosin heavy chain IIx/d antibody;Myosin-1 antibody;skeletal muscle antibody

SUBCELLULAR LOCATION

Cytoplasm, myofibril.

FUNCTION

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail. Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Class II Myosins are hexameric proteins composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals, at least ten different myosin heavy chain (MYH) isoforms have been described from striated, smooth, but rarely in non-muscle cells. These isoforms show expression that is spatially and temporally regulated during development.