Methyltransferase-like 26 Rabbit Polyclonal Antibody (ER1803-45)

UNIPROT #

Q96S19

PROTEIN NAME

Methyltransferase-like 26

SYNONYMS

2610100D03Rik antibody;2810013M15Rik antibody;A830095F14Rik antibody;AI846133 antibody;Methyltransferase 10 domain containing antibody;Methyltransferase like 16 antibody;METT10D antibody;MGC3329 antibody;OTTMUSP00000006473 antibody;Putative methyltransferase METT10D antibody;RP23-174M12.2 antibody

SEQUENCE SIMILARITIES

Belongs to the UPF0585 family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

METTL26, previously designated C16orf13, is a protein-coding gene for Methyltransferase Like 26, also known as JFP2. Though the function of this gene is unknown, various data have revealed that it is expressed at high levels in various cancerous tissues. Underexpression of this gene has also been linked to disease consequences in humans. The human expression profile from NCBI UniGene suggests that this gene has widespread expression in many different tissues in the body. This expression profile suggests that this gene is a “housekeeping gene,” one that has important effects in all cells, regardless of tissue. The highest levels of expression appear to be in the adrenal gland, lung, and parathyroid. There are many additional sites besides these highest three where the gene is expressed in high levels. There seems to be no real similarity in the few tissues where the gene is not expressed. This expression data does not seem to give any clues into specific function, except to suggest that the gene is involved in a “housekeeping” function of nearly all cells. The protein that this gene codes for is known as UPF0585, where UPF signals unknown protein function. There are five isoforms of this protein, corresponding to the five splice variants of the gene. The isoforms are named a, b, c, d, and g As mentioned above, the conserved domain detected in a BLAST search of this amino acid sequence is a methyltransferase superfamily