Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody [SD080-02] (ET1612-65)

UNIPROT #

P07101

PROTEIN NAME

Tyrosine Hydroxylase

SYNONYMS

Dystonia 14 antibody;DYT14 antibody;DYT5b antibody;EC 1.14.16.2 antibody;OTTHUMP00000011225 antibody;OTTHUMP00000011226 antibody;ple antibody;Protein Pale antibody;TH antibody;The antibody;TY3H_HUMAN antibody;TYH antibody;Tyrosine 3 hydroxylase antibody;Tyrosine 3 monooxygenase antibody;Tyrosine 3-hydroxylase antibody;Tyrosine 3-monooxygenase antibody;Tyrosine hydroxylase antibody

SEQUENCE SIMILARITIES

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

TISSUE SPECIFICITY

Mainly expressed in the brain and adrenal glands.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds.