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ACE2 Recombinant Rabbit Monoclonal Antibody [SN0754] (ET1611-58)

Price: Regular price $385.00

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Catalog# ET1611-58

Rabbit Monoclonal to ACE2

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • IF-Tissue

  • IP

Reacts with

  • Human

  • Mouse

  • Rat

  • Hamster

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

ACE2 Recombinant Rabbit Monoclonal Antibody [SN0754] (ET1611-58)

Immunogen

Synthetic peptide within human ace2 aa 181-230 / 805.

Host

Rabbit

Positive Control

HepG2 cell lysate, 293T cell lysate, rat brain tissue lysate, rat kidney tissue lysate, human kidney tissue lysate, human small intestine tissue lysate, mouse kidney tissue lysate, mouse testis tissue lysate, hamster testis lysates, hamster stomach tissue lysates, 293, MCF-7, HepG2, human kidney tissue, human testis tissue, mouse kidney tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SN0754

RRID

AB_3070037

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IF-Cell

  • 1:100-1:500

  • IHC-P

  • 1:1,000

  • IF-Tissue

  • 1:200

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 92 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9BYF1

PROTEIN NAME

ACE2

SYNONYMS

ACE 2 antibody;ACE related carboxypeptidase antibody;ACE-related carboxypeptidase antibody;ACE2 antibody;ACE2_HUMAN antibody;ACEH antibody;Angiotensin converting enzyme 2 antibody;Angiotensin converting enzyme homolog antibody;Angiotensin converting enzyme like protein antibody;Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2 antibody;Angiotensin I converting enzyme 2 antibody;Angiotensin-converting enzyme homolog antibody;DKFZP434A014 antibody;EC 3.4.17 antibody;metalloprotease MPROT 15 antibody;Metalloprotease MPROT15 antibody;OTTHUMP00000022963 antibody;Processed angiotensin-converting enzyme 2 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M2 family.

TISSUE SPECIFICITY

Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells (at protein level). Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in the renal proximal tubule and the small intestine (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.

POST-TRANSLATIONAL MODIFICATION

N-glycosylation on Asn-90 may limit SARS infectivity.; Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Cytoplasm, Membrane, Secreted.

FUNCTION

Angiotensin-converting enzyme (ACE) is a carboxyl-terminal dipeptidyl exopeptidase that converts angiotensin I to the potent vasopressive hormone, angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/electrolyte homeostasis. ACE2 is the first known human homolog of ACE. Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells.

CITATIONS

  • Fengjie Huang

    Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis

  • Chen, H., Yu, B., Guo, X., Hua, H., Cui, F., Guan, Y., Tian, Y., Zhang, X., Zhang, Y., & Ma, H.

    Chronic Intermittent Hypobaric Hypoxia Decreases High Blood Pressure by Stabilizing the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats. Frontiers in physiology, 12, 639454.

  • Chang-Fa Fan;Yu-Sen Zhou;Cheng-Feng Qin;You-Chun Wang

    A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

  • Wang Yaohe,et al

    Genomic-transcriptomic analysis reveals Syrian hamster as a superior human disease animal model

  • Liu, F. L., Wu, K., Sun, J., Duan, Z., Quan, X., Kuang, J., Chu, S., Pang, W., Gao, H., Xu, L., Li, Y. C., Zhang, H. L., Wang, X. H., Luo, R. H., Feng, X. L., Schöler, H. R., Chen, X., Pei, D., Wu, G., Zheng, Y. T., … Chen, J.

    Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation. National Science Review, nwaa285.

  • Yu, B., Chen, H., Guo, X. Q., Hua, H., Guan, Y., Cui, F., Tian, Y. M., Zhang, H. X., Zhang, X. J., Zhang, Y., & Ma, H. J.

    CIHH protects the heart against left ventricular remodelling and myocardial fibrosis by balancing the renin-angiotensin system in SHR. Life sciences, 278, 119540.

  • Tao Guoa,Fengjie Huang

    Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway

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