NGF Recombinant Rabbit Monoclonal Antibody [SI79-01] (ET1606-29)

UNIPROT #

P01138

PROTEIN NAME

NGF

SYNONYMS

Beta nerve growth factor antibody;Beta NGF antibody;Beta-nerve growth factor antibody;Beta-NGF antibody;HSAN5 antibody;MGC161426 antibody;MGC161428 antibody;Nerve growth factor (beta polypeptide) antibody;Nerve growth factor antibody;Nerve growth factor beta antibody;Nerve growth factor beta polypeptide antibody;Nerve growth factor beta subunit antibody;NGF antibody;NGF_HUMAN antibody;NGFB antibody;NID67 antibody

SEQUENCE SIMILARITIES

Belongs to the NGF-beta family.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). In fact, NGF is critical for the survival and maintenance of sympathetic and sensory neurons, as they undergo apoptosis in its absence. However, several recent studies suggest that NGF is also involved in pathways besides those regulating the life cycle of neurons. NGF can drive the expression of genes such as bcl-2 by binding to the Tropomyosin receptor kinase A, which stimulates the proliferation and survival of the target neuron. There is evidence that pancreatic beta cells express both the TrkA and p75NTR receptors of NGF. It has been shown that the withdrawal of NGF induces apoptosis in pancreatic beta cells, signifying that NGF may play a critical role in the maintenance and survival of pancreatic beta cells. NGF plays a critical role in the regulation of both innate and acquired immunity. In the process of inflammation, NGF is released in high concentrations by mast cells, and induces axonal outgrowth in nearby nociceptive neurons. This leads to increased pain perception in areas under inflammation. In acquired immunity, NGF is produced by the Thymus as well as CD4+ T cell clones, inducing a cascade of maturation of T cells under infection.