NUR77 Recombinant Rabbit Monoclonal Antibody [JM59-11] (ET1703-97)

UNIPROT #

P22736

PROTEIN NAME

NUR77

SYNONYMS

Early response protein NAK1 antibody;GFRP 1 antibody;GFRP antibody;GFRP1 antibody;Growth factor inducible nuclear protein N10 antibody;Growth Factor Inducible Nuclear Protein NP10 antibody;Growth Factor Response Protein 1 antibody;Hbr1 antibody;HMR antibody;Hormone Receptor antibody;MGC9485 antibody;N10 antibody;N10 nuclear protein antibody;NAK 1 antibody;NAK1 antibody;Nerve growth factor IB nuclear receptor variant 1 antibody;NGFIB antibody;NP 10 antibody;NP10 antibody;NR4A1 antibody;NR4A1_HUMAN antibody;Nuclear hormone receptor NUR/77 antibody;Nuclear Hormone Receptor TR3 antibody;Nuclear receptor subfamily 4 group A member 1 antibody;NUR77 antibody;NUR77, mouse, homolog of antibody;Orphan nuclear receptor HMR antibody;Orphan nuclear receptor NR4A1 antibody;Orphan nuclear receptor TR3 antibody;Orphan receptor tr3 antibody;Receptor NGFIB antibody;ST 59 antibody;ST-59 antibody;ST59 antibody;Steroid receptor TR3 antibody;Testicular receptor 3 antibody;TR 3 antibody;TR3 antibody;TR3 orphan receptor antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR4 subfamily.

TISSUE SPECIFICITY

Fetal muscle and adult liver, brain and thyroid.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.; Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus. Nucleus membrane.

FUNCTION

Nurr1 (Nur-related factor 1) and Nur77 (also designated NGFI-B) encode orphan nuclear receptors which may comprise an additional subfamily within the nuclear receptor superfamily. The rat and human homologs of mouse Nurr1 are designated RNR1 and NOT, respectively. Both Nurr1 and Nur77 are growth factor inducible immediate early response genes. Induction of both Nurr1 and Nur77 is seen after membrane depolarization while only Nur77 induction is seen with NGF stimulation. JunD acts as a mediator for Nur77. An increase in Nur77 expression is seen in activated T cells during G0 to G1 transition and throughout the G1 phase. In addition to its function as an immediate early gene, Nur77 may play a role in TCR-mediated apoptosis. Cyclosporin A, a potent immunosuppressant, has been shown to inhibit the ability of Nur77 to bind DNA. A dominant negative form of Nur77 can protect T cell hybridomas from activation-induced apoptosis. However, the absolute requirement of Nur77 for TCR-mediated apoptosis is still under debate.