Axin2 Recombinant Rabbit Monoclonal Antibody [JM11-30] (ET1703-96)

UNIPROT #

Q9Y2T1

PROTEIN NAME

Axin2

SYNONYMS

Axil antibody;Axin like protein antibody;Axin-2 antibody;Axin-like protein antibody;Axin2 antibody;AXIN2_HUMAN antibody;Axis inhibition protein 2 antibody;Conductin antibody;DKFZp781B0869 antibody;MGC10366 antibody;MGC126582 antibody

TISSUE SPECIFICITY

Expressed in brain and lymphoblast.

POST-TRANSLATIONAL MODIFICATION

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.; ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.; Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway.