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Cdk2 Recombinant Rabbit Monoclonal Antibody [SR01-01] (ET1602-6)

Price: Regular price $385.00

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Catalog# ET1602-6

Rabbit Monoclonal to Cdk2

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • IP

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Cdk2 Recombinant Rabbit Monoclonal Antibody [SR01-01] (ET1602-6)

Immunogen

Synthetic peptide within human cdk2 aa 249-298 / 298.

Host

Rabbit

Positive Control

A549 cell lysate, F9 cell lysate, Hela, CRC, SH-SY5Y, N2A, human tonsil tissue, human spleen tissue, mouse spleen tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SR01-01

RRID

AB_3069663

APPLICATION DILUTION

  • WB

  • 1:500-1:5,000

  • IF-Cell

  • 1:50-1:200

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • IP

  • Use at an assay dependent concentration.

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 34 kDa

Isotype

IgG

TARGET

UNIPROT #

P24941

PROTEIN NAME

Cdk2

SYNONYMS

Cdc2 related protein kinase antibody;cdc2-related protein kinase antibody;CDC28 antibody;CDC2A antibody;Cdk 2 antibody;CDK1 antibody;CDK2 antibody;CDK2_HUMAN antibody;CDKN2 antibody;Cell devision kinase 2 antibody;Cell division protein kinase 2 antibody;Cyclin dependent kinase 2 antibody;cyclin dependent kinase 2-alpha antibody;Cyclin-dependent kinase 2 antibody;kinase Cdc2 antibody;MPF antibody;p33 protein kinase antibody;p33(CDK2) antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.; Nitrosylated after treatment with nitric oxide (DETA-NO).

SUBCELLULAR LOCATION

Endosome, Cytoplasm, Nucleus, Cajal body, Centrosome.

FUNCTION

Cyclin-dependent kinase 2 (p33CDK2) is an important component of the cell cycle machinery. It acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Inhibition of CDK2-cyclin complexes can also be attributed to association with p27 Kip1 and p21 Waf1/Cip1.

CITATIONS

  • Jiang Huangyu,et al

    Evodiamine Inhibits the Progression of Esophageal Aquamous Cell Carcinoma via Modulating PI3K/AKT/mTOR Pathway

  • Companion-Probe & Race platform for interrogating nuclear protein and migration of living cells

  • Chao Shen

    Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling

  • Nanoengineered Gallium Ion Incorporated Formulation for Safe and Efficient Reversal of PARP Inhibition and Platinum Resistance in Ovarian Cancer

  • Wang K

    N-myc downstream regulated gene 1(NDRG1) promotes the stem-like properties of lung cancer cells through stabilized c-Myc

  • CDK2 and CDK4 targeted liensinine inhibits the growth of bladder cancer T24 cells

  • Lei Tao,et al

    Hydrochlorothiazide disrupts DNA damage response to exacerbate skin photosensitivity

  • Pan Dan,et al

    Acetyl-11-keto-beta-boswellic acid inhibits cell proliferation and growth of oral squamous cell carcinoma via RAB7B-mediated autophagy

  • Pharmacological investigation of indole alkaloids from Alstonia scholaris against chronic glomerulonephritis

  • Sun Yuliang,et al

    Intelligent drugs based on notch protein remodeling: a defensive targeting strategy for tumor therapy

  • Wang Xinyu,et al

    Pterostilbene, a Resveratrol Derivative, Improves Ovary Function by Upregulating Antioxidant Defenses in the Aging Chickens via Increased SIRT1/Nrf2 Expression

  • Liu, X., Cui, S., Dan, C., Li, W., Xie, H., Li, C., & Shi, L.

    Phellinus baumii Polyphenol: A Potential Therapeutic Candidate against Lung Cancer Cells

  • Ziwei Liang

    SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways.

  • Elucidation of the anti-colon cancer mechanism of Phellinus baumii polyphenol by an integrative approach of network pharmacology and experimental verification

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