Cyclin D3 Recombinant Rabbit Monoclonal Antibody [SD20-43] (ET1612-4)

UNIPROT #

P30281

PROTEIN NAME

Cyclin D3

SYNONYMS

CCND 3 antibody;Ccnd3 antibody;CCND3_HUMAN antibody;CyclinD3 antibody;D3 type cyclin antibody;G1 S specific cyclin D3 antibody;G1/S specific cyclin D3 antibody;G1/S-specific cyclin-D3 antibody

SEQUENCE SIMILARITIES

Belongs to the cyclin family. Cyclin D subfamily.

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Membrane.

FUNCTION

The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl-1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors.