Cortactin Recombinant Rabbit Monoclonal Antibody [SC61-08] (ET1610-87)

UNIPROT #

Q14247

PROTEIN NAME

Cortactin

SYNONYMS

Amplaxin antibody;CTTN antibody;EMS 1 antibody;EMS1 antibody;FLJ34459 antibody;Mammary tumor and squamous cell carcinoma associated antibody;Oncogene EMS1 antibody;p80/85 src substrate antibody;Src substrate cortactin antibody;SRC8_HUMAN antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.

SUBCELLULAR LOCATION

Cytoplasm, Cell projection, Membrane.

FUNCTION

Cortactin (also designated Ems-1) is a filamentous Actin (F-Actin) binding protein that has been shown to be a substrate for Src p60. Cortactin contains tandem 37 amino acid repeats at the amino-terminus and an SH3 domain at the carboxy-terminus. The tandem repeats appear to be necessary for F-Actin binding. Tyrosine phosphorylation of Cortactin by Src p60 results in diminished F-Actin binding to Cortactin and reduced F-Actin cross-linking activity. Cortactin has also been shown to be phosphorylated in response to FGF-1. Cortactin exhibits abundant expression in megakaryocytes and platelets, and it may play a role in the maturation of megakaryocytes.