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Geminin Rabbit Polyclonal Antibody (R1204-2)

Price: Regular price $315.00

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Catalog# R1204-2

Rabbit Polyclonal to Geminin

Tested for

  • WB

  • IF-Cell

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

Geminin Rabbit Polyclonal Antibody (R1204-2)

Immunogen

Synthetic peptide within human geminin aa 1-50 / 209.

Host

Rabbit

Positive Control

Hela cell lysates, NCCIT, F9, HepG2.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073197

APPLICATION DILUTION

  • WB

  • 1:500

  • IF-Cell

  • 1:50

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

24 kDa

Isotype

IgG

TARGET

UNIPROT #

O75496

PROTEIN NAME

Geminin

SYNONYMS

DNA replication inhibitor antibody;Gem antibody;GEMI_HUMAN antibody;Geminin antibody;Geminin DNA replication inhibitor antibody;GMNN antibody;OTTHUMP00000039393 antibody;RP3 369A17.3 antibody

SEQUENCE SIMILARITIES

Belongs to the geminin family.

DEVELOPMENTAL STAGE

Absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.

SUBCELLULAR LOCATION

Nucleus, cytoplasm

FUNCTION

Geminin is a nuclear protein that is present in most eukaryotics and highly conserved across species. Numerous functions have been elucidated for Geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation. During S phase, geminin is a negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNAi results in re-replication of portions of the genome, which leads to aneuploidy.

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