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CaMKII alpha Recombinant Rabbit Monoclonal Antibody [JM11-07] (ET1703-54)

Price: Regular price $385.00

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Catalog# ET1703-54

Rabbit Monoclonal to CaMKII alpha

Tested for

  • WB

  • IHC-P

  • IF-Tissue

  • IHC-Fr

  • IF-Cell

  • FC

  • IP

Reacts with

  • Human

  • Mouse

  • Rat

  • Cynomolgus monkey

  • Pig

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

CaMKII alpha Recombinant Rabbit Monoclonal Antibody [JM11-07] (ET1703-54)

Immunogen

Synthetic peptide within human camkii alpha aa 37-71 / 478.

Specificity

This antibody detects endogenous levels of total camkii protein. the peptide sequence used as the antigen is 100% conserved between camkii-alpha, gamma, delta and beta.

Host

Rabbit

Positive Control

Mouse brain tissue, rat brain tissue lysates, rat testis tissue, mouse cerebellum tissue, rat brain tissue, Neuro-2a.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM11-07

RRID

AB_3070410

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

  • IHC-P

  • 1:200-1:500

  • IF-Tissue

  • 1:500-1:1,000

  • IHC-Fr

  • 1:200-1:500

  • IF-Cell

  • 1:100-1:500

  • FC

  • 1:50-1:100

  • IP

  • 1:10-1:50

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 54 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9UQM7

PROTEIN NAME

CaMKII alpha

SYNONYMS

Alpha CaMKII antibody;Calcium calmodulin dependent protein kinase II antibody;Calcium/calmodulin dependent protein kinase II alpha B subunit antibody;Calcium/calmodulin dependent protein kinase type II alpha chain antibody;Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha antibody;Calcium/calmodulin-dependent protein kinase II alpha antibody;Calcium/calmodulin-dependent protein kinase II-alpha antibody;Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody;Calcium/calmodulin-dependent protein kinase type IIA antibody;CaM kinase II alpha chain antibody;CaM kinase II alpha subunit antibody;CaM kinase II subunit alpha antibody;CaMK II alpha subunit antibody;CaMK-II subunit alpha antibody;Camk2a antibody;CAMKA antibody;CaMKII antibody;CaMKIINalpha antibody;EC 2.7.11.17 antibody;KCC2A_HUMAN antibody;KIAA0968 antibody;MGC123320 antibody;MGC139375 antibody;MGC155201 antibody;mKIAA0968 antibody;PK2CDD antibody;PKCCD antibody;R74975 antibody;zgc:112538 antibody;zgc:123320 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state.; Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.

SUBCELLULAR LOCATION

Cell junction, Cell projection, Synapse.

FUNCTION

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.

CITATIONS

  • Li, Q. Y., Duan, Y. W., Zhou, Y. H., Chen, S. X., Li, Y. Y., & Zang, Y.

    NLRP3-Mediated Piezo1 Upregulation in ACC Inhibitory Parvalbumin-Expressing Interneurons Is Involved in Pain Processing after Peripheral Nerve Injury

  • Unilateral injection of botulinum toxin type A into the masseter muscle induces mandibular asymmetry in adolescent rats by suppressing the angular process growth

  • Lei Jie,et al

    Alternating bilateral sensory stimulation alleviates alcohol-induced conditioned place preference via a superior colliculus-VTA circuit

  • Artesunate Suppresses Choroidal Melanoma Vasculogenic Mimicry Formation and Angiogenesis via the Wnt/CaMKII Signaling Axis

  • Na Liu,et al

    Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner

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