Bcl10 Recombinant Rabbit Monoclonal Antibody [SN74-04] (ET1611-79)

UNIPROT #

O95999

PROTEIN NAME

Bcl10

SYNONYMS

AI132454 antibody;B cell CLL/lymphoma 10 antibody;B cell lymphoma/leukemia10 antibody;B-cell CLL/lymphoma 10 antibody;B-cell leukemia/lymphoma 10 antibody;B-cell lymphoma/leukemia 10 antibody;Bcl 10 antibody;Bcl-10 antibody;Bcl10 antibody;BCL10_HUMAN antibody;c E10 antibody;c-E10 antibody;C81403 antibody;CARD containing apoptotic signaling protein antibody;CARD containing molecule enhancing NF kappa B antibody;CARD containing molecule enhancing NF kB antibody;CARD containing molecule enhancing NF-kB antibody;CARD containing molecule enhancing NFkB antibody;CARD containing proapoptotic protein antibody;CARD like apoptotic protein antibody;CARD-containing apoptotic signaling protein antibody;CARD-containing molecule enhancing NF-kappa-B antibody;CARD-containing proapoptotic protein antibody;CARD-like apoptotic protein antibody;CARMEN antibody;Caspase recruiting domain containing protein antibody;caspase-recruiting domain-containing protein antibody;cCARMEN antibody;cE 10 antibody;cE10 antibody;CED 3/ICH 1 prodomain homologous E10 like regulator antibody;CED-3/ICH-1 prodomain homologous E10-like regulator antibody;CED3/ICH1 prodomain homologous E10 like regulator antibody;Cellular E10 antibody;Cellular homolog of vCARMEN antibody;Cellular-E10 antibody;CIPER antibody;CLAP antibody;hCLAP antibody;Mammalian CARD containing adapter molecule E10 antibody;Mammalian CARD-containing adapter molecule E10 antibody;mE 10 antibody;mE10 antibody;R-RCD1 antibody

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.

SUBCELLULAR LOCATION

Cytoplasm, Membrane raft.

FUNCTION

Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl10 is homologous to the equine herpesvirus-2 E10 gene and, like E10, it contains an N-terminal caspase recruitment domain (CARD). Expression of Bcl10 has been shown to induce NFκB activation in a NIK-dependent pathway, and research indicates that the CARD domain is essential for this activation; although in a separate study, Bcl10 by itself did not induce JNK or NFκB activation. Overexpression of Bcl10 has been shown to induce apoptosis in a manner dependent on CARD-mediated oligomerization. Bcl10 has also been shown to play a role in processing of caspase-9 to its active dimer. Other studies have shown that Bcl10 is not mutated in many human tumors and lymphomas.