Integrin alpha 4 Recombinant Rabbit Monoclonal Antibody [JA09-36] (ET1704-31)

UNIPROT #

P13612

PROTEIN NAME

Integrin alpha 4

SYNONYMS

269C wild type antibody;Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody;CD49 antigen like family member D antibody;CD49 antigen-like family member D antibody;CD49d antibody;IA4 antibody;Integrin alpha 4 antibody;Integrin alpha 4 subunit antibody;Integrin alpha IV antibody;Integrin alpha-4 antibody;Integrin alpha-IV antibody;Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody;ITA4_HUMAN antibody;ITGA4 antibody;MGC90518 antibody;OTTHUMP00000205320 antibody;Very late activation protein 4 receptor, alpha 4 subunit antibody;VLA 4 subunit alpha antibody;VLA-4 subunit alpha antibody;VLA4 antibody

SEQUENCE SIMILARITIES

Belongs to the LAMP family.

TISSUE SPECIFICITY

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver. Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta.

POST-TRANSLATIONAL MODIFICATION

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.