LAMP1 Recombinant Rabbit Monoclonal Antibody [JJ0940] (ET1701-94)

UNIPROT #

P11279

PROTEIN NAME

LAMP1

SYNONYMS

CD107 antigen like family member A antibody;CD107 antigen-like family member A antibody;CD107a antibody;CD107a antigen antibody;LAMP 1 antibody;LAMP-1 antibody;LAMP1 antibody;LAMP1_HUMAN antibody;LAMPA antibody;LGP120 antibody;lgpA antibody;Lysosomal membrane glycoprotein 120KD antibody;Lysosomal Associated Membrane Protein 1 antibody;Lysosome associated membrane glycoprotein 1 antibody;Lysosome-associated membrane glycoprotein 1 antibody;Lysosome-associated membrane protein 1 antibody;OTTHUMP00000040663 antibody

SEQUENCE SIMILARITIES

Belongs to the LAMP family.

POST-TRANSLATIONAL MODIFICATION

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.

SUBCELLULAR LOCATION

Cell membrane, Endosome membrane, Lysosome membrane, Late endosome.

FUNCTION

Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. The human LAMP1 gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34).Immunofluorescence staining of HeLa Cells with antibody to reveal lysosomal LAMP1 in red and vimentin containing intermediate filaments in green. Nuclear DNA is seen in blue. Antibodies and image courtesy EnCor Biotechnology Inc.Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins.The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types.It resides primarily across lysosomal membranes,and functions to provide selectins with carbohydrate ligands. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells. and may also play a role in tumor cell differentiation and metastasis.