LAMP2a Recombinant Rabbit Monoclonal Antibody [SA46-01] (ET1601-24)

UNIPROT #

P13473

PROTEIN NAME

LAMP2a

SYNONYMS

CD107 antigen-like family member B antibody;CD107b antibody;LAMP 2 antibody;Lamp 2a antibody;LAMP-2 antibody;LAMP2 antibody;LAMP2_HUMAN antibody;Lysosome-associated membrane glycoprotein 2 antibody;Lysosome-associated membrane protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the LAMP family.

TISSUE SPECIFICITY

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver. Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta.

POST-TRANSLATIONAL MODIFICATION

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.

SUBCELLULAR LOCATION

Cell membrane, Endosome membrane, Lysosome membrane

FUNCTION

Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of the gene produces three variants - LAMP-2A, LAMP-2B and LAMP-2C. LAMP-2A is the receptor for chaperone-mediated autophagy. Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis. LAMP-2B is associated with Danon disease.