ABCG2 Recombinant Rabbit Monoclonal Antibody [JF0994] (ET1702-40)

UNIPROT #

Q9UNQ0

PROTEIN NAME

ABCG2

SYNONYMS

ABC transporter antibody;ABC15 antibody;ABCG 2 antibody;ABCG2 antibody;ABCG2_HUMAN antibody;ABCP antibody;ATP binding cassette sub family G (WHITE) member 2 antibody;ATP binding cassette transporter G2 antibody;ATP-binding cassette sub-family G member 2 antibody;BCRP antibody;BCRP1 antibody;BMDP antibody;Breast cancer resistance protein antibody;CD338 antibody;CDw338 antibody;CDw338 antigen antibody;EST157481 antibody;GOUT1 antibody;MGC102821 antibody;Mitoxantrone resistance associated protein antibody;Mitoxantrone resistance-associated protein antibody;MRX antibody;Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody;MXR antibody;MXR1 antibody;Placenta specific ATP binding cassette transporter antibody;Placenta specific MDR protein antibody;Placenta-specific ATP-binding cassette transporter antibody;UAQTL1 antibody

SEQUENCE SIMILARITIES

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

TISSUE SPECIFICITY

Highly expressed in placenta. Low expression in small intestine, liver and colon. Expressed in brain (at protein level).

POST-TRANSLATIONAL MODIFICATION

N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional.; Phosphorylated. Phosphorylation at Thr-362 by PIM1 is induced by drugs like mitoxantrone and is associated with cells increased drug resistance. It regulates the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.

SUBCELLULAR LOCATION

Mitochondrion membrane, Cell membrane, Apical cell membrane.

FUNCTION

ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extracellular and intracellular membranes through the energy of ATP hydrolysis. The ABC half-transporter, ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placenta, liver, intestine and stem cells.