Topoisomerase II alpha Mouse Monoclonal Antibody [A3F12] (HA601028)

UNIPROT #

P11388

PROTEIN NAME

Topoisomerase II alpha

SYNONYMS

alpha isozyme antibody;ATP hydrolyzing DNA topoisomerase II alfa antibody;DNA gyrase antibody;DNA topoisomerase (ATP hydrolyzing) antibody;DNA topoisomerase 2 alpha antibody;DNA topoisomerase 2-alpha antibody;DNA topoisomerase II 170 kD antibody;DNA topoisomerase II alpha isozyme antibody;DNA topoisomerase II antibody;DNA Topoisomerase2 antibody;TOP 2A antibody;TOP2 antibody;TOP2A antibody;TOP2A_HUMAN antibody;Topoisomerase DNA II alpha 170kDa antibody;TP2A antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relives topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several chemotherapy agents and a variety of mutations in this gene have been associated with the development of drug resistance.[citation needed] Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. TOP2A has been shown to interact with SMURF2, HDAC1, CDC5L, Small ubiquitin-related modifier 1 and P53.