E2F1 Recombinant Rabbit Monoclonal Antibody [JJ092-02] (ET1701-73)

UNIPROT #

Q01094

PROTEIN NAME

E2F1

SYNONYMS

DmelCG6376 antibody;Dmel_CG6376 antibody;drosE2F1 antibody;E(Sev-CycE)3A antibody;E(var)3-93E antibody;E2-promoter binding facto antibody;E2F 1 antibody;E2F transcription factor 1 antibody;E2F-1 antibody;E2f-PA antibody;E2f-PB antibody;E2f-PC antibody;E2F1 antibody;E2f1 E2F transcription factor 1 antibody;E2F1_HUMAN antibody;Evar(3)164 antibody;KIAA4009 antibody;l(3)07172 antibody;l(3)j3B1 antibody;l(3)j3C2 antibody;l(3)rM729 antibody;mKIAA4009 antibody;OTTHUMP00000030661 antibody;PBR3 antibody;PRB binding protein E2F 1 antibody;PRB-binding protein E2F-1 antibody;RBAP 1 antibody;RBAP-1 antibody;RBAP1 antibody;RBBP-3 antibody;RBBP3 antibody;RBP 3 antibody;RBP3 antibody;Retinoblastoma-associated protein 1 antibody;Retinoblastoma-binding protein 3 antibody;Transcription factor E2F1 antibody

SEQUENCE SIMILARITIES

Belongs to the E2F/DP family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.; Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcription regulators including E2F-2, E2F-3, E2F-4, E2F-5, E2F-6 and E2F-7 each of which forms heterodimers with a second protein, DP-1, forming an "active" E2F transcriptional regulatory complex.