SRC1 Recombinant Rabbit Monoclonal Antibody [JB66-31] (ET7107-44)

UNIPROT #

Q15788

PROTEIN NAME

SRC1

SYNONYMS

bHLHe74 antibody;Class E basic helix-loop-helix protein 74 antibody;F SRC 1 antibody;Hin 2 protein antibody;Hin2 protein antibody;MGC129719 antibody;MGC129720 antibody;mNRC 1 antibody;NCoA 1 antibody;NCoA-1 antibody;Ncoa1 antibody;NCOA1_HUMAN antibody;Nuclear receptor coactivator 1 antibody;Nuclear receptor coactivator protein 1 antibody;NY REN 52 antigen antibody;Protein Hin 2 antibody;Protein Hin-2 antibody;Protein Hin2 antibody;Renal carcinoma antigen NY REN 52 antibody;Renal carcinoma antigen NY-REN-52 antibody;RIP 160 antibody;RIP160 antibody;SRC 1 antibody;SRC-1 antibody;Steroid receptor coactivator 1 antibody

SEQUENCE SIMILARITIES

Belongs to the SRC/p160 nuclear receptor coactivator family.

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.; Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Nuclear receptors for steroids, thyroid hormones and retinoic acids are ligand-dependent transcription factors that activate transcription through specific DNA binding sites in their target genes. Several related transcriptional coactivators and corepressors have been described that work in concert with the steroid receptor family to either induce or repress transcription from hormone-responsive elements. This family includes GRIP1 (for GR interacting protein 1, also designated NCoA-2 or Tif2); SRC-1 (for steroid receptor coactivator-1, also designated NCoA-1); RAC3 (also designated AIB1, for amplified in breast cancer, or ACTR), which displays elevated expression in estrogen receptor positive ovarian and breast cancers; and p/CIP (for p300/CBP/Co-Integrator Protein), which is required for the transcriptional activation of p300/CBP-dependent transcription factors. The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression. NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).