LKB1 Rabbit Polyclonal Antibody (HA500143)

UNIPROT #

Q15831

PROTEIN NAME

LKB1

SYNONYMS

hLKB1 antibody;Liver kinase B1 antibody;LKB1 antibody;PJS antibody;Polarization related protein LKB1 antibody;Renal carcinoma antigen NY-REN-19 antibody;Serine/Threonine Kinase 11 antibody;Serine/threonine protein kinase 11 antibody;Serine/threonine protein kinase LKB1 antibody;Serine/threonine protein kinase STK11 antibody;Serine/threonine-protein kinase 11 antibody;Serine/threonine-protein kinase LKB1 antibody;Serine/threonine-protein kinase XEEK1 antibody;Stk11 antibody;STK11_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, Membrane, Mitochondrion, Nucleus.

FUNCTION

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways.