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ATG12 Rabbit Polyclonal Antibody (R1404-1)

Price: Regular price $315.00

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Catalog# R1404-1

Rabbit Polyclonal to ATG12

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

ATG12 Rabbit Polyclonal Antibody (R1404-1)

Immunogen

Synthetic peptide within human atg12 aa 96-138.

Host

Rabbit

Positive Control

Rat kidney, HCT116

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073293

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IF-Cell

  • 1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 15 kDa

Isotype

IgG

TARGET

UNIPROT #

O94817

PROTEIN NAME

ATG12

SYNONYMS

APG12-like antibody;APG12L antibody;ATG12 antibody;ATG12 autophagy related 12 homolog (S. cerevisiae) antibody;ATG12 autophagy related 12 homolog antibody;ATG12_HUMAN antibody;Autophagy 12 antibody;Autophagy-related protein 12 antibody;FBR93 antibody;HAPG12 antibody;Ubiquitin-like protein ATG12 antibody

SEQUENCE SIMILARITIES

Belongs to the ATG12 family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Acetylated by EP300.

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene. Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy. Autophagy requires the covalent attachment of the protein Atg12 to ATG5 through a ubiquitin-like conjugation system. The Atg12-Atg5 conjugate then promotes the conjugation of ATG8 to the lipid phosphatidylethanolamine. Atg12 was found to be involved in apoptosis. This protein promotes apoptosis through an interaction with anti-apoptotic members of the Bcl-2 family.

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