ATG4B Recombinant Rabbit Monoclonal Antibody [JE59-97] (HA721334)

UNIPROT #

Q9Y4P1

PROTEIN NAME

ATG4B

SYNONYMS

APG4 autophagy 4 homolog B antibody;APG4B antibody;ATG4 autophagy related 4 homolog B (S. cerevisiae) antibody;ATG4B antibody;ATG4B_HUMAN antibody;AUT like 1 cysteine endopeptidase antibody;AUT-like 1 cysteine endopeptidase antibody;AUTL1 antibody;Autophagin 1 antibody;Autophagin-1 antibody;Autophagy related 4B cysteine peptidase antibody;Autophagy related cysteine endopeptidase 1 antibody;Autophagy related protein 4 homolog B antibody;Autophagy-related cysteine endopeptidase 1 antibody;Autophagy-related protein 4 homolog B antibody;Cysteine protease ATG4B antibody;hAPG4B antibody;MGC1353 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Cytoplasmic vesicle, autophagosome, Endoplasmic reticulum, Mitochondrion.

FUNCTION

Cysteine protease ATG4B is an enzyme that in humans is encoded by the ATG4B gene. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. One main function of Atg4 is to cleave the pre-protein of Atg8, leading to the non-lipidated soluble (-I) form which can be processed further by Atg3, Atg7, Atg5-12 into the lipidated form (-II) anchored to the autophagic membrane.