CDC42 Recombinant Rabbit Monoclonal Antibody [JJ086-04] (ET1701-7)

UNIPROT #

P60953

PROTEIN NAME

CDC42

SYNONYMS

CDC42 antibody;CDC42_HUMAN antibody;CDC42Hs antibody;Cell division control protein 42 homolog antibody;Cell division cycle 42 (GTP binding protein 25kDa) antibody;Cell division cycle 42 antibody;dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)) antibody;dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)) antibody;G25K antibody;G25K GTP-binding protein antibody;Growth regulating protein antibody;GTP binding protein 25kDa antibody;Small GTP binding protein CDC42 antibody;TKS antibody

SEQUENCE SIMILARITIES

Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.

POST-TRANSLATIONAL MODIFICATION

(Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.; Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI.; (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of CDC42 and leads to actin disassembly.

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane.

FUNCTION

The superfamily of GTP-binding proteins, for which the Ras proteins are prototypes, has been implicated in regulation of diverse biological activities involving various aspects of cell growth and division. One mammalian member of the family, Cdc42, has an amino acid sequence that is similar to those of various members of the Ras superfamily proteins, including N-, K- and H-Ras, Rho proteins and the Rac proteins. On the basis of in vitro phosphorylation studies, it has been suggested that human Cdc42 may function in the signaling pathway of the EGF receptor or related growth factor receptor protein kinases. The Dbl oncogene has been shown to specifically catalyze dissociation of GDP from human Cdc42.