Rab4A Recombinant Rabbit Monoclonal Antibody [SR27-08] (ET1602-15)

UNIPROT #

P20338

PROTEIN NAME

Rab4A

SYNONYMS

HRES 1 / RAB4 antibody;Oncogene RAB4 antibody;Rab 4 antibody;RAB 4A antibody;RAB4 member RAS oncogene family antibody;Rab4a antibody;RAB4A member RAS oncogene family antibody;RAB4A_HUMAN antibody;Ras related protein Rab 4A antibody;Ras related protein Rab4A antibody;Ras-related protein Rab-4A antibody

SEQUENCE SIMILARITIES

Belongs to the small GTPase superfamily. Rab family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CDK1 kinase during mitosis.

SUBCELLULAR LOCATION

Cytoplasm, Membrane

FUNCTION

The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab superfamilies, exhibits 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possiblity that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab family have been identified, each of which is found at a particular stage of a membrane transport pathway.