Rac1-2-3 Recombinant Rabbit Monoclonal Antibody [JM11-29] (ET1703-80)

UNIPROT #

P63000

PROTEIN NAME

Rac1-2-3

SYNONYMS

Cell migration inducing gene 5 protein antibody;EN 7 antibody;OTTMUSP00000004488 antibody;p21 Rac3 antibody;p21-Rac3 antibody;Rac1B antibody;RAC3 antibody;RAC3_HUMAN antibody;RAS related C3 botulinum substrate 3 antibody;Ras related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3) antibody;Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) antibody;Ras-related C3 botulinum toxin substrate 3 antibody;Rho family small GTP binding protein Rac3 antibody;RP23-84C12.18 antibody;EN-7 antibody;EN7 antibody;GX antibody;HSPC 022 antibody;HSPC022 antibody;p21 Rac 2 antibody;p21 Rac2 antibody;p21-Rac2 antibody;p21Rac2 antibody;RAC 2 antibody;Rac2 antibody;RAC2_HUMAN antibody;Ras related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2 antibody;Ras related C3 botulinum toxin substrate 2 antibody;Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac2) antibody;Ras related C3 botulinum toxin substrate 3 antibody;Ras-related C3 botulinum toxin substrate 2 antibody;Rho family small GTP binding protein Rac 2 antibody;Rho family small GTP binding protein Rac2 antibody;Small G protein antibody;Cell migration-inducing gene 5 protein antibody;MGC111543 antibody;MIG5 antibody;Migration inducing gene 5 antibody;Migration inducing protein 5 antibody;p21 Rac1 antibody;p21-Rac1 antibody;Rac 1 antibody;RAC1 antibody;RAC1_HUMAN antibody;Ras like protein TC25 antibody;Ras related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) antibody;Ras-like protein TC25 antibody;Ras-related C3 botulinum toxin substrate 1 antibody;Rho family small GTP binding protein Rac1 antibody;TC 25 antibody;TC25 antibody

SEQUENCE SIMILARITIES

Belongs to the small GTPase superfamily. Rho family.

TISSUE SPECIFICITY

Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.

POST-TRANSLATIONAL MODIFICATION

(Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.; GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome.; (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane.

FUNCTION

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.