Galectin 8 Recombinant Rabbit Monoclonal Antibody [JB85-35] (ET7107-56)

UNIPROT #

O00214

PROTEIN NAME

Galectin 8

SYNONYMS

Gal 8 antibody;Gal-8 antibody;Gal8 antibody;Galectin-8 antibody;galectin-8g antibody;Lectin galactoside binding soluble 8 antibody;LEG8_HUMAN antibody;LGAL S8 antibody;Lgals8 antibody;PCTA 1 antibody;PCTA-1 antibody;PCTA1 antibody;Po66 carbohydrate binding protein antibody;Po66 carbohydrate-binding protein antibody;Po66 CBP antibody;Po66-CBP antibody;Prostate carcinoma tumor antigen 1 antibody

TISSUE SPECIFICITY

Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Galectin-8 is a protein of the galectin family that in humans is encoded by the LGALS8 gene. This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. Galectin-8, interacts with the mTOR regulatory system composed of SLC38A9, Ragulator, RagAB, RagCD. Galectin-8 controls mTOR causing its inactivation and dissociation from damaged lysosomes, hence transducing the breach of the lysosomal membrane to mTOR. The physiological consequences of mTOR inhibition following lysosomal membrane damage[8] encompass autophagy and metabolic switching.