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MelanA Recombinant Rabbit Monoclonal Antibody [SC56-02] (ET1610-47)

Price: Regular price $385.00

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Catalog# ET1610-47

Rabbit Monoclonal to MelanA

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Mouse

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

MelanA Recombinant Rabbit Monoclonal Antibody [SC56-02] (ET1610-47)

Immunogen

Synthetic peptide within human melana aa 2-43 / 118.

Host

Rabbit

Positive Control

Melanoma tissue lysate, B16F1 cell lysate, human melanoma tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SC56-02

RRID

AB_3069932

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 13 kDa

Isotype

IgG

TARGET

UNIPROT #

Q16655

PROTEIN NAME

MelanA

SYNONYMS

Antigen LB39 AA antibody;Antigen LB39-AA antibody;Antigen SK29 AA antibody;Antigen SK29-AA antibody;MAR1_HUMAN antibody;MART 1 antibody;MART-1 antibody;MART1 antibody;Melan A antibody;Melan A protein antibody;Melanoma antigen recognized by T cells 1 antibody;Melanoma antigen recognized by T-cells 1 antibody;MLAN A antibody;MLANA antibody;OTTHUMP00000021036 antibody;OTTHUMP00000021037 antibody;OTTHUMP00000021038 antibody;Protein Melan-A antibody

TISSUE SPECIFICITY

Expression is restricted to melanoma and melanocyte cell lines and retina.

POST-TRANSLATIONAL MODIFICATION

Acylated.

SUBCELLULAR LOCATION

Golgi apparatus, trans-Golgi network membrane, Endoplasmic reticulum membrane, Melanosome.

FUNCTION

Melanoma-associated antigens recognized by cytotoxic T lymphocytes (CTL) have been grouped into three categories: melanocyte differentiation antigens, cancer/testis-specific antigens and mutated or aberrantly expressed antigens. Many of these antigens consist of peptides that are presented to T cells by HLA molecules; they represent potential targets for cancer immunotherapy. Melan-A (also designated MART-1) is a melanocyte differentiation antigen that is specific to melanomas, melanocyte cell lines and retina. Melan-A peptide is recognized by most HLA-A2-restricted tumor-specific tumor-infiltrating lymphocytes in patients with melanoma. Antimelanoma cytotoxic T lymphocytes can be generated with a Melan-A peptide, implicating Melan-A as a potential candidate for antigen-specific immunotherapy in melanoma patients.

CITATIONS

  • Yu Jinhai,et al

    Three-Dimensional Cell Spheroid Culture and Proliferation Activity Study of Uveal Melanoma Cell Line C918

  • Zhang, Y., Zeng, H., Hu, Y., Jiang, L., Fu, C., Zhang, L., Zhang, F., Zhang, X., Zhu, L., Huang, J., Chen, J., & Zeng, Q.

    Establishment and validation of evaluation models for post-inflammatory pigmentation abnormalities

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