IL-17 Rabbit Polyclonal Antibody (ER1706-91)

UNIPROT #

Q16552

PROTEIN NAME

IL-17

SYNONYMS

CTLA 8 antibody;CTLA-8 antibody;CTLA8 antibody;Cytotoxic T lymphocyte associated antigen 8 antibody;Cytotoxic T lymphocyte associated protein 8 antibody;Cytotoxic T lymphocyte associated serine esterase 8 antibody;Cytotoxic T-lymphocyte-associated antigen 8 antibody;IL 17A antibody;IL-17 antibody;IL-17A antibody;IL17 antibody;IL17_HUMAN antibody;Il17a antibody;Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody;Interleukin 17A antibody;Interleukin-17A antibody;Interleukin17 antibody;Interleukin17A antibody;OTTHUMP00000016597 antibody;OTTMUSP00000046003 antibody

SEQUENCE SIMILARITIES

Belongs to the IL-17 family.

TISSUE SPECIFICITY

Restricted to activated memory T-cells.

POST-TRANSLATIONAL MODIFICATION

Found both in glycosylated and nonglycosylated forms.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.