MMP-11 Recombinant Rabbit Monoclonal Antibody [SN74-08] (ET1611-33)

UNIPROT #

P24347

PROTEIN NAME

MMP-11

SYNONYMS

Matrix Metalloproteinase 11 antibody;Matrix metalloproteinase-11 antibody;MMP-11 antibody;Mmp11 antibody;MMP11_HUMAN antibody;SL 3 antibody;SL-3 antibody;SL3 antibody;ST3 antibody;STMY3 antibody;Stromelysin 3 antibody;Stromelysin III antibody;Stromelysin-3 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M10A family.

TISSUE SPECIFICITY

Specifically expressed in stromal cells of breast carcinomas.

POST-TRANSLATIONAL MODIFICATION

The precursor is cleaved by a furin endopeptidase.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also called stromelysin-1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.