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MMP-12 Recombinant Rabbit Monoclonal Antibody [SR03-23] (ET1602-42)

Price: Regular price $385.00

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Catalog# ET1602-42

Rabbit Monoclonal to MMP-12

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • IP

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

MMP-12 Recombinant Rabbit Monoclonal Antibody [SR03-23] (ET1602-42)

Immunogen

Synthetic peptide within human mmp12 aa 421-470 / 470.

Host

Rabbit

Positive Control

A549 cell lysate, Hela cell lysate, MCF-7 cell lysate, THP-1 cell lysate, human breast carcinoma tissue lysate, mouse lung tissue lysate, rat lung tissue lysate.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SR03-23

RRID

AB_3069655

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IF-Cell

  • 1:20-1:50

  • IF-Tissue

  • 1:20-1:50

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 54 kDa

Isotype

IgG

TARGET

UNIPROT #

P39900

PROTEIN NAME

MMP-12

SYNONYMS

EC 3.4.24.65 antibody;HME antibody;Macrophage elastase antibody;Macrophage metalloelastase antibody;Macrophage metaloelastase antibody;Matrix metallopeptidase 12 (macrophage elastase) antibody;Matrix metalloprotease 12 antibody;Matrix metalloproteinase-12 antibody;ME antibody;MGC138506 antibody;MME antibody;MMP 12 antibody;MMP-12 antibody;Mmp12 antibody;MMP12_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M10A family.

TISSUE SPECIFICITY

Found in alveolar macrophages but not in peripheral blood monocytes.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.

CITATIONS

  • Geng, F., Xu, M., Zhao, L., Zhang, H., Li, J., Jin, F., Li, Y., Li, T., Yang, X., Li, S., Gao, X., Cai, W., Mao, N., Sun, Y., Liu, H., Xu, H., Wei, Z., & Yang, F.

    Quercetin Alleviates Pulmonary Fibrosis in Mice Exposed to Silica by Inhibiting Macrophage Senescence

  • Li Tian,et al

    Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models

  • Che, L. H., Liu, J. W., Huo, J. P., Luo, R., Xu, R. M., He, C., Li, Y. Q., Zhou, A. J., Huang, P., Chen, Y. Y., Ni, W., Zhou, Y. X., Liu, Y. Y., Li, H. Y., Zhou, R., Mo, H., & Li, J. M.

    A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

  • Liao Chengyu,et al

    Necroptosis enhances 'don't eat me' signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis

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