MMP-7 Rabbit Polyclonal Antibody (HA500305)

UNIPROT #

P09237

PROTEIN NAME

MMP-7

SYNONYMS

Matrilysin antibody;Matrin antibody;Matrix Metalloproteinase 7 antibody;Matrix metalloproteinase-7 antibody;MMP 7 antibody;MMP-7 antibody;MMP7 antibody;MMP7_HUMAN antibody;MPSL1 antibody;PUMP 1 antibody;Pump 1 protease antibody;Pump-1 protease antibody;PUMP1 antibody;Uterine matrilysin antibody;Uterine metalloproteinase antibody

SUBCELLULAR LOCATION

Extracellular matrix, Secreted.

FUNCTION

MMP7 was initially characterized by Woessner et al. It digests components of the extracellular matrix, cleaves the α 2 (I) chain of gelatin more rapidly, and digests the B chain of insulin at Ala14-Leu and Tyr16-Leu, and has no action on collagen types I, II, IV, V. The optimal pH of MMP7 is at 7 and the pI is at 5.9. MMP4 is inhibited by α 2-macroglobulin and TIMP. The inhibition of MMP7 activity commonly relies on metal-chelating agents including EDTA and 1,10-phenantroline, especially zinc chelation. Therefore, the selectivity of MMP7 inhibition is challenging since almost all members of MMPs family contain catalytic domains with zinc binding sites. TIMP-1 and 2 noncovalently bound to active MMP7 at the catalytic site inhibiting MMP7 activity. The activated MMP7 can also cleave the propeptides of proMMP2 and proMMP9 to facilitate tumor invasion.