TNF Receptor I Rabbit Polyclonal Antibody (HA500140)

UNIPROT #

P19438

PROTEIN NAME

TNF Receptor I

SYNONYMS

CD120a antibody;FPF antibody;MGC19588 antibody;p55 antibody;p55-R antibody;p60 antibody;TBP1 antibody;TBPI antibody;TNF R antibody;TNF R55 antibody;TNF-R1 antibody;TNF-RI antibody;TNFAR antibody;TNFR-I antibody;TNFR1 antibody;TNFR55 antibody;TNFR60 antibody;TNFRI antibody;TNFRSF1a antibody;TNR1A_HUMAN antibody;Tumor necrosis factor receptor 1 antibody;Tumor necrosis factor receptor superfamily, member 1A antibody;Tumor necrosis factor receptor type 1 antibody;Tumor necrosis factor receptor type I antibody;Tumor necrosis factor-binding protein 1 antibody

SUBCELLULAR LOCATION

Secreted, Cell membrane, Golgi apparatus membrane.

FUNCTION

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.