Ephrin B2 Recombinant Rabbit Monoclonal Antibody [JM53-21] (ET1705-33)

UNIPROT #

P52799

PROTEIN NAME

Ephrin B2

SYNONYMS

EFN B2 antibody;EFNB 2 antibody;Efnb2 antibody;EFNB2_HUMAN antibody;Eph related receptor tyrosine kinase ligand 5 antibody;EPH-related receptor tyrosine kinase ligand 5 antibody;ephrin B2 antibody;Ephrin-B2 antibody;EphrinB2 antibody;EPLG 5 antibody;EPLG5 antibody;Htk L antibody;HTK ligand antibody;HTK-L antibody;HTKL antibody;LERK 5 antibody;LERK-5 antibody;LERK5 antibody;Ligand of eph related kinase 5 antibody;MGC126226 antibody;MGC126227 antibody;MGC126228 antibody;OTTMUSP00000024973 antibody

SEQUENCE SIMILARITIES

Belongs to the ephrin family.

TISSUE SPECIFICITY

Lung and kidney.

POST-TRANSLATIONAL MODIFICATION

Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. EFNB2 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, EFNB2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.