Kidins220 Rabbit Polyclonal Antibody (ER1902-65)

UNIPROT #

Q9ULH0

PROTEIN NAME

Kidins220

SYNONYMS

Ankyrin repeat-rich membrane-spanning protein antibody;arms antibody;KDIS_HUMAN antibody;kidins220 antibody;Kinase D interacting substance of 220 kDa antibody;Kinase D-interacting substrate of 220 kDa antibody;rgd 619949 antibody

TISSUE SPECIFICITY

Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF) (By similarity).

SUBCELLULAR LOCATION

Late endosome, membrane.

FUNCTION

This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants.