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CTGF Rabbit Polyclonal Antibody (ER1802-69)

Price: Regular price $315.00

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Catalog# ER1802-69

Rabbit Polyclonal to CTGF

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

CTGF Rabbit Polyclonal Antibody (ER1802-69)

Immunogen

Recombinant protein within human ctgf aa 147-293 / 349.

Host

Rabbit

Positive Control

Mouse smooth muscle tissue lysate, HepG2, HUVEC, SiHa, human endometrium tissue, mouse smooth muscle tissue, rat smooth muscle tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069167

APPLICATION DILUTION

  • WB

  • 1:500

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 38 kDa

Isotype

IgG

TARGET

UNIPROT #

P29279

PROTEIN NAME

CTGF

SYNONYMS

CCN 2 antibody;CCN family member 2 antibody;CCN2 antibody;Connective tissue growth factor antibody;Ctgf antibody;CTGF_HUMAN antibody;Hcs 24 antibody;Hcs24 antibody;Hypertrophic chondrocyte specific protein 24 antibody;Hypertrophic chondrocyte-specific gene product 24 antibody;Hypertrophic chondrocyte-specific protein 24 antibody IBP-8 antibody;IGF-binding protein 8 antibody;IGFBP-8 antibody;IGFBP8 antibody;Insulin like Growth Factor Binding Protein 8 antibody;Insulin-like growth factor-binding protein 8 antibody;MGC102839 antibody;NOV 2 antibody;NOV2 antibody

SEQUENCE SIMILARITIES

Belongs to the CCN family.

TISSUE SPECIFICITY

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix

FUNCTION

Connective tissue growth factor (CTGF, also known as hypertrophic chondrocyte-specific gene product 24 or Hcs24), is a member of the CCN family of immediate early proteins, which are involved in cell proliferation, migration and matrix production. CTGF is a cysteine-rich peptide that is secreted by endothelial cells, fibroblasts, smooth muscle cells and myofibroblasts. Its expression is increased in various human and animal fibrotic diseases. Specifically, CTGF has been observed to be strongly upregulated in human proliferative and fibrogenic renal disease. In addition, CTGF is a growth factor for vascular smooth muscle cells (VSMC) and may play a similar role in promoting VSMC growth and migration in vitro.

CITATIONS

  • Ming Wu,Chaoyang Ye

    Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.

  • Icariin attenuates renal fibrosis in chronic kidney disease by inhibiting interleukin‐1β/transforming growth factor‐β‐mediated activation of renal fibroblasts

  • Shen Shuai II Recipe inhibits hypoxia-induced glycolysis by preserving mitochondrial dynamics to attenuate kidney fibrosis

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