CD59 Recombinant Rabbit Monoclonal Antibody [JM10-71] (ET1703-28)

UNIPROT #

P13987

PROTEIN NAME

CD59

SYNONYMS

16.3A5 antibody;1F5 antibody;1F5 antigen antibody;20 kDa homologous restriction factor antibody;CD 59 antibody;CD_antigen=CD59 antibody;CD59 antibody;CD59 antigen antibody;CD59 antigen complement regulatory protein antibody;CD59 antigen p18 20 antibody;CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) antibody;CD59 glycoprotein antibody;CD59 molecule antibody;CD59 molecule complement regulatory protein antibody;CD59_HUMAN antibody;Cd59a antibody;Complement regulatory protein antibody;EJ16 antibody;EJ30 antibody;EL32 antibody;FLJ38134 antibody;FLJ92039 antibody;G344 antibody;HRF 20 antibody;HRF-20 antibody;HRF20 antibody;Human leukocyte antigen MIC11 antibody;Ly 6 like protein antibody;Lymphocytic antigen CD59/MEM43 antibody;MAC inhibitory protein antibody;MAC IP antibody;MAC-inhibitory protein antibody;MAC-IP antibody;MACIF antibody;MACIP antibody;MEM43 antibody;MEM43 antigen antibody;Membrane attack complex (MAC) inhibition factor antibody;Membrane attack complex inhibition factor antibody;Membrane inhibitor of reactive lysis antibody;MGC2354 antibody;MIC11 antibody;MIN1 antibody;MIN2 antibody;MIN3 antibody;MIRL antibody;MSK21 antibody;p18 20 antibody;Protectin antibody;Surface antigen recognized by monoclonal antibody;16.3A5 antibody;T cell activating protein antibody

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.; Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.

SUBCELLULAR LOCATION

Cell membrane. Secreted.

FUNCTION

CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family. CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex. It may also signal the cell to perform active measures such as endocytosis of the CD59-C9 complex. Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria. Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.