TCF7L2 Recombinant Rabbit Monoclonal Antibody [SC06-90] (ET1610-73)

UNIPROT #

Q9NQB0

PROTEIN NAME

TCF7L2

SYNONYMS

HMG box transcription factor 4 antibody;hTCF 4 antibody;hTCF-4 antibody;T cell factor 4 antibody;T cell specific HMG box antibody;T cell specific transcription factor 4 antibody;T-cell factor 4 antibody;T-cell-specific transcription factor 4 antibody;TCF 4 antibody;TCF-4 antibody;TCF4 antibody;TCF7L2 antibody;TCF7L2 protein antibody;TF7L2_HUMAN antibody;Transcription factor 7 like 2 antibody;Transcription factor 7 like 2 T cell specific HMG box antibody;Transcription factor 7-like 2 antibody

SEQUENCE SIMILARITIES

Belongs to the TCF/LEF family.

TISSUE SPECIFICITY

Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.

DEVELOPMENTAL STAGE

Highly expressed in crypt regions and barely detectable in villi in epithelium from fetal small intestine at week 16. At week 22 expression in villi had increased strongly.

POST-TRANSLATIONAL MODIFICATION

In vitro, phosphorylated by TNIK.; Phosphorylated at Thr-201 and/or Thr-212 by NLK. Phosphorylation by NLK at these sites inhibits DNA-binding by TCF7L2/TCF4, thereby preventing transcriptional activation of target genes of the canonical Wnt/beta-catenin signaling pathway.; Polysumoylated. Sumoylation is enhanced by PIAS family members and desumoylation is enhanced by SENP2. Sumoylation/desumoylation regulates TCF7L2/TCF4 transcription activity in the Wnt/beta-catenin signaling pathway without altering interaction with CTNNB1 nor binding to DNA.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β-catenin in a cooperative manner. This TCF-4/β-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes. c-Jun also interacts with TCF-4 and β-catenin, and the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin. TCF-4 is also implicated in bipolar affective disorder.