NHE-1 Rabbit Polyclonal Antibody (ER1902-51)

UNIPROT #

P19634

PROTEIN NAME

NHE-1

SYNONYMS

amiloride-sensitive antibody;APNH antibody;APNH1 antibody;FLJ42224 antibody;Na Li countertransporter antibody;Na(+)/H(+) antiporter antibody;Na(+)/H(+) exchanger 1 antibody;Na+ H+ antiporter amiloride-sensitive antibody;Na+ H+ antiporter antibody;Na+ H+ exchanger 1 antibody;NHE-1 antibody;NHE1 antibody;OTTHUMP00000004468 antibody;SL9A1_HUMAN antibody;SLC9A1 antibody;Sodium / Hydrogen Exchanger 1 antibody;Sodium hydrogen exchanger 1 antibody;Sodium/hydrogen exchanger 1 antibody;solute carrier family 9 antibody;Solute carrier family 9 member 1 antibody;Solute carrier family 9 sodium hydrogen exchanger isoform 1 antiporter Na+ H+ amiloride sensitive antibody;Solute carrier family 9 subfamily A (NHE1 cation proton antiporter 1) member 1 antibody;Solute carrier family 9 subfamily A member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

TISSUE SPECIFICITY

Kidney and intestine.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated.; Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).

SUBCELLULAR LOCATION

Cell membrane, Endoplasmic reticulum, Membrane.

FUNCTION

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II and CHP. It is also the target of the experimental drug rimeporide, which is being developed for the treatment of Duchenne muscular dystrophy.