SERCA1 ATPase Recombinant Rabbit Monoclonal Antibody [JE45-75] (ET7109-43)

UNIPROT #

O14983

PROTEIN NAME

SERCA1 ATPase

SYNONYMS

fast twitch skeletal muscle isoform antibody;AT2A1_HUMAN antibody;ATP2A antibody;ATP2A1 antibody;ATPase Ca++ transporting cardiac muscle fast twitch 1 antibody;ATPase Ca++ transporting fast twitch 1 antibody;ATPase, Ca(2+)-transporting fast twitch 1 antibody;Calcium pump 1 antibody;Calcium transporting ATPase sarcoplasmic reticulum type fast twitch skeletal muscle isoform antibody;Calcium-transporting ATPase sarcoplasmic reticulum type antibody;EC 3.6.3.8 antibody;Endoplasmic reticulum class 1/2 Ca(2+) ATPase antibody;Fast skeletal muscle SR calcium ATPase antibody;OTTHUMP00000162561 antibody;OTTHUMP00000162562 antibody;Sarcoendoplasmic reticulum calcium ATPase antibody;Sarcoplasmic reticulum Ca(2+)-ATPase 1 antibody;Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 antibody;SERCA 1 antibody;SERCA1 antibody;SERCA1 truncated isoform, included antibody;SR Ca(2+) ATPase 1 antibody;SR Ca(2+)-ATPase 1 antibody

SEQUENCE SIMILARITIES

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.

TISSUE SPECIFICITY

Skeletal muscle, fast twitch muscle (type II) fibers.

DEVELOPMENTAL STAGE

Isoform SERCA1A accounts for more than 99% of SERCA1 isoforms expressed in adult skeletal muscle, while isoform SERCA1B predominates in neo-natal skeletal muscle.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Sarcoplasmic reticulum membrane.

FUNCTION

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. There are 3 major domains on the cytoplasmic face of SERCA: the phosphorylation and nucleotide-binding domains, which form the catalytic site, and the actuator domain, which is involved in the transmission of major conformational changes. It seems that, in addition to the calcium-transporting properties, SERCA1 generates heat in some adipocytes and can improve cold tolerance in some wood frogs.