Apolipoprotein A1 Recombinant Rabbit Monoclonal Antibody [JF0548] (ET1702-23)

UNIPROT #

P02647

PROTEIN NAME

Apolipoprotein A1

SYNONYMS

Apo-AI antibody;ApoA I antibody;ApoA-I antibody;APOA1 antibody;APOA1_HUMAN antibody;Apolipoprotein A-I(1-242) antibody;Apolipoprotein A1 antibody;Apolipoprotein AI antibody;Brp14 antibody;Ltw1 antibody;Lvtw1 antibody;Sep1 antibody;Sep2 antibody

SEQUENCE SIMILARITIES

Belongs to the apolipoprotein A1/A4/E family.

TISSUE SPECIFICITY

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.; Palmitoylated.; Phosphorylation sites are present in the extracellular medium.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the APOA1 gene.As the major component of HDL particles, it has a specific role in lipid metabolism.Apolipoprotein AI is the major protein component of high density lipoprotein (HDL) particles in plasma.[10] Chylomicrons secreted from the intestinal enterocyte also contain apo-AI, but it is quickly transferred to HDL in the bloodstream.[11] The protein, as a component of HDL particles, enables efflux of fat molecules by accepting fats from within cells (including macrophages within the walls of arteries which have become overloaded with ingested fats from oxidized LDL particles) for transport (in the water outside cells) elsewhere, including back to LDL particles or to the liver for excretion. It is a cofactor for lecithin—cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Apolipoprotein AI has also been isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect.[12] Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.Apo-AI is often used as a biomarker for prediction of cardiovascular diseases. The ratio apoB-100/apoA1 (i.e. LDL & larger particles vs. HDL particles), NMR measured lipoprotein (low density lipoprotein (LDL)/(HDL) particle ratios even more so, has always had a stronger correlation with myocardial infarction event rates than older methods of measuring lipid transport in the water outside cells. Apo-AI is routinely measured using immunoassays such as ELISA or nephelometry.