LDL Receptor Rabbit Polyclonal Antibody (R1512-12)

UNIPROT #

P01130

PROTEIN NAME

LDL Receptor

SYNONYMS

FH antibody;FHC antibody;LDL R antibody;LDL receptor antibody;LDLCQ2 antibody;Ldlr antibody;LDLR_HUMAN antibody;Low Density Lipoprotein Receptor antibody;Low density lipoprotein receptor class A domain containing protein 3 antibody;Low density lipoprotein receptor familial hypercholesterolemia antibody;Low-density lipoprotein receptor antibody

SEQUENCE SIMILARITIES

Belongs to the LDLR family.

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated.; Ubiquitinated by MYLIP leading to degradation.

SUBCELLULAR LOCATION

Golgi apparatus, Plasma membrane, Endosome, Lysosome, Cell membrane.

FUNCTION

LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR, and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease, familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.